About Immunotherapy

Immunotherapy: A Long History

Allergy immunotherapy is the only therapy that has been clinically proven to diminish or eliminate allergy symptoms. It has been used in clinical settings for respiratory allergies for more than 100 years in the form of anti-allergy shots (subcutaneous immunotherapy, or SCIT), formulated drops (sublingual immunotherapy, or SLIT), and tablets.

Immunotherapy introduces small amounts of purified, allergy-triggering proteins (allergens) to the body in a carefully controlled way. This can fundamentally change how the body responds to allergens over the course of therapy. It is the only disease-modifying approach to allergy treatment. While symptom reduction usually occurs in the first few months of treatment, patients are more likely to obtain persistent reduction of allergy symptoms when immunotherapy treatment continues for 3-5 years.

Current Challenges

Immunotherapy is used by only 4% of the more than 60 million respiratory allergy sufferers in the United States. One reason for this low rate of use is the difficulty most patients have with adhering to the necessary long-term administration of treatment. Patients must commit to weekly visits to the doctor’s office for allergy shots or daily self-administration of messy, imprecise liquid drops under the tongue.

OMIT Solves Pressing Problems

Oral mucosal immunotherapy (OMIT) is a novel method of allergy immunotherapy administered using the Allerdent® immunotherapy platform. OMIT delivers immunotherapeutic agents to the areas of the oral cavity with the highest concentration of Langerhans Cells (LCs), a type of antigen-presenting cell. These immune system cells have been shown to be pivotal in reducing allergic sensitivity. By targeting these cells, the OMIT approach increases the likelihood of decreasing allergy symptoms and improving the health of allergy sufferers.

OMIT supports long-term patient commitment to treatment by integrating immunotherapy into an individual’s everyday tooth brushing routine. Since adherence is key to producing a lasting reduction in symptoms, this simple innovation has the potential to improve outcomes for allergy treatment.